Which neurotransmitters are involved in contextually modulated analgesia according to studies?

The choice indicating that endorphins, cholecystokinin, dopamine, and anandamide are involved in contextually modulated analgesia is supported by various studies emphasizing the complexity of pain modulation in response to contextual factors.

Endorphins play a significant role in pain relief by binding to opioid receptors, thus reducing the perception of pain. Cholecystokinin is linked to pain modulation and can influence the efficacy of analgesia. Dopamine is known for its role in reward mechanisms and can affect pain perception and emotional responses related to it. Anandamide, a cannabinoid neurotransmitter, also has analgesic properties and is part of the endocannabinoid system, which modulates pain perception and emotional states in relation to pain.

Together, these neurotransmitters create a comprehensive network that facilitates the dynamic changes in pain perception influenced by context, such as environmental cues or psychological states. This multifaceted interaction helps explain how different conditions or contexts can enhance or diminish the experience of pain, underscoring the complexity of the body’s response to pain and the need for integrated treatment approaches in chiropractic and pain management.